>>> myList = list(range(1,5))
>>> myList
[1, 2, 3, 4]
>>> myList = myList[:-1]
>>> myList
[1, 2, 3]
>>> some_list = [1, 2, 3]
>>> some_list[-1] = 5 # Set the last element
>>> some_list[-2] = 3 # Set the second to last element
>>> some_list
[1, 3, 5]