df.loc[:, df.columns != 'b']
a c d
0 0.561196 0.013768 0.772827
1 0.882641 0.615396 0.075381
2 0.368824 0.651378 0.397203
3 0.788730 0.568099 0.869127df[df.columns.difference(['b'])]
Out:
a c d
0 0.427809 0.459807 0.333869
1 0.678031 0.668346 0.645951
2 0.996573 0.673730 0.314911
3 0.786942 0.719665 0.330833
df[df.columns.drop('b')]